Clinical Trials

As we develop new therapies, additional trials will be opened.

Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/ Metastatic Solid Tumors Including Mesothelioma


Currently recruiting patients
Call: +44 20 8135 8316

Refer a patient

This is an open-label, non-randomized, multicenter, translational Phase 1/2 dose-escalation and expansion study designed to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of RSO-021 after intrapleural (IP) administration in patients with malignant pleural effusion (MPE) (non-mesothelioma) and MPE from mesothelioma.


    • Mesothelioma with malignant pleural effusion

    • Metastatic disease to the lung with malignant pleural effusion

    • Metastic ovarian and breast cancer with malignant pleural effusion

Research Study Locations

South Mead North Bristol Hopsital
Contact: Louise Standon -
Principal Investigator: Nick Maskell, BMSci BM BS FRCP DM FCCP
Bristol, United Kingdom, BS105NB
NHS Greater Glasgow & Clyde
Contact: Stephanie Hughes
Principal Investigator: Kevin Blyth, MBBS
Glasgow, United Kingdom
Leeds Teaching Hospital
Principal Investigator: Kevin Franks, MBChB
Leeds, United Kingdom, LS970F
HOPE Clinical Trials Facility, Leicester Royal Infirmary
Contact: Molly Scotland,
Principal Investigator: Dean Fennell, FRCP PhD
Leicester, United Kingdom, LE1 5WW
Barts Health NHS Cancer Institute
Contact: Maria Lapuente,
Principal Investigator: Peter Szlosarek, MD PhD
London, United Kingdom, EC1A7BE
Guys and St Thomas NHS Foundation Trust
Contact: George Borley,
Principal Investigator: James Spicer, FRCP PhD MRCP MBBS
London, United Kingdom, SE19RT
The Royal Marsden
Contact: Bianca Peet,
Principal Investigator: Sanjay Popat, BSc MBBS FRCP PhD
London, United Kingdom, SW3 6JJ
The Christie NHS
Contact: Amy Henshaw,
Principal Investigator: Fiona Thistlethwaite, MB BChir PhD MRCP
Manchester, United Kingdom, M204BX
Northumbria NorthTyne Side General Hospital
Contact: Jessica Reynolds,
Principal Investigator: Avinash Aujayeb, MD
North Shields, United Kingdom, NE29 8NH
Oxford University Hospitals NHS Foundation
Contact: David Mukkath,
Principal Investigator: Simon Lord, BM BS MRCP PhD
Oxford, United Kingdom, OX42PG
London (3)
North Shields

We are pleased to partner with the following institutions who also strive to improve and expand access to care