Clinical Trials

As we develop new therapies, additional trials will be opened.

Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/ Metastatic Solid Tumors Including Mesothelioma

MITOPE RESEARCH STUDY
ClinicalTrials.gov #NCT05278975

Currently recruiting patients
Call: +44 20 8135 8316
Email: mitope@rsoncology.com

Refer a patient

TRIAL DESIGN:
This is an open-label, non-randomized, multicenter, translational Phase 1/2 dose-escalation and expansion study designed to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of RSO-021 after intrapleural (IP) administration in patients with malignant pleural effusion (MPE) (non-mesothelioma) and MPE from mesothelioma.

DISEASE:

    • Mesothelioma with malignant pleural effusion

    • Metastatic disease to the lung with malignant pleural effusion

    • Metastic ovarian and breast cancer with malignant pleural effusion

Research Study Locations

NHS Greater Glasgow & Clyde
Contact: Stephanie Hughes
stephanie.hughes@ggc.scot.nhs.uk
Principal Investigator: Kevin Blyth, MBBS
Glasgow, United Kingdom
Leeds Teaching Hospital
Contact: leedsth-tr.earlyphaseadmin@nhs.net
Principal Investigator: Kevin Franks, MBChB
Leeds, United Kingdom, LS970F
HOPE Clinical Trials Facility, Leicester Royal Infirmary
Contact: Molly Scotland, molly.scotland@uhl-tr.nhs.uk
Principal Investigator: Dean Fennell, FRCP PhD
Leicester, United Kingdom, LE1 5WW
Barts Health NHS Cancer Institute
Contact: Maria Lapuente, m.lapuente@nhs.net
Principal Investigator: Peter Szlosarek, MD PhD
London, United Kingdom, EC1A7BE
Guys and St Thomas NHS Foundation Trust
Contact: George Borley, earlyphaseresearchteam@gstt.nhs.uk
Principal Investigator: James Spicer, FRCP PhD MRCP MBBS
London, United Kingdom, SE19RT
The Christie NHS
Contact: Amy Henshaw, amy.henshaw@nhs.net
Principal Investigator: Fiona Thistlethwaite, MB BChir PhD MRCP
Manchester, United Kingdom, M204BX
Sheffield Teaching Hospitals NHS Foundation Trust
Contact: coming soon
Principal Investigator: Duneesha De-Fonseka
Clinical Research & Innovation Office
Sheffield Royal Hallamshire Hospital, Broomhill, Glossop Rd, Sheffield S10 2JF, United Kingdom
Oxford University Hospitals NHS Foundation
Contact: David Mukkath, trialadministrator4@oncology.ox.ac.uk
Principal Investigator: Simon Lord, BM BS MRCP PhD
Oxford, United Kingdom, OX42PG
map
Glasgow
Leeds
Leicester
London (2)
Manchester
Sheffield
Oxford

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